The current study investigated the relationships between internalizing and externalizing (I‐E) behaviors and family variables, including both parenting stress and quality of attachment relations, in children aged 8–12 with high‐functioning autism spectrum disorder (ASD) or with typical development. Compared to the group with typical development, children with ASD exhibited significantly greater levels of psychopathology as assessed by the Child Behavior Checklist [Achenbach, 1991], and parents of children with ASD exhibited higher parenting stress as assessed by the Parenting Stress Index [Abidin, 1995]. In a hierarchical multiple regression analysis, parenting stress emerged as the most important predictor of children's I‐E problems. Results are discussed in light of the two groups' similar relationships between parenting stress and child psychopathology.