… To study endogenous communication across the brain and periphery, we explored Cre-mediated
DNA recombination to permanently record the functional uptake of bdEVs cargo overtime. To
elucidate functional cargo transfer within the brain at physiological levels, we promoted the
continuous secretion of physiological levels of neural bdEVs containing Cre mRNA from a
localized region in the brain by in situ lentiviral transduction of the striatum of Flox-tdTomato Ai9
mice reporter of Cre activity. Our approach efficiently detected in vivo transfer of functional …

In the central nervous system (CNS), the crosstalk between neural cells is mediated by
extracellular mechanisms, including brain-derived extracellular vesicles (bdEVs). To study
endogenous communication across the brain and periphery, we explored Cre-mediated
DNA recombination to permanently record the functional uptake of bdEVs cargo over time.
To elucidate functional cargo transfer within the brain at physiological levels, we promoted
the continuous secretion of physiological levels of neural bdEVs containing Cre mRNA from …