… FLT3 are now recognized as the most common molecular abnormality in acute myeloid
leukemia, and FLT3 … The poor prognosis of patients harboring these mutations renders FLT3 an …

… FLT3 is greatly involved in the pathophysiology of leukemia, and that both mutations and
expression levels of FLT3 distinguish a disease entity of leukemia… ficance of FLT3 for leukemia. …

… the FLT3/ITD mutation and, moreover, the leukemia cells appear to be more “FLT3 addicted”
with regard to in vitro response to FLT3 … Occasionally, an FLT3/ITD mutation detected at …

… the importance of FLT3 in leukemia was the finding of FLT3 mutations. … FLT3 signaling.
More work remains to elucidate the complete signaling pathway altered by FLT3 in leukemia. …

… of targeting FLT3 in AML and acute lymphocytic leukemia (ALL) … FLT3 is highly expressed
in most acute leukemias.2, 3 In acute myeloid leukemia (AML) and acute lymphocytic leukemia …

… Our attempts to treat the disease known as acute myeloid leukemia with a FLT3 internal
tandem duplication (FLT3/ITD AML) mutation certainly could be characterized as an intervention …

… , and 89% of acute myelogenous leukemia (AML). Moreover, constitutive activation of FLT3
can occur in leukemia cells through 2 mechanisms: coexpression of FLT3 ligand (FL), which …

… with an FLT3/ITD, we have analyzed outcome according to FLT3 status … FLT3/ITD + patients,
we have performed a donor-versus–no donor analysis in the 683 patients in whom the FLT3…

… -mutated AML (the study included two patients with other acute leukemias and a minority
of patients without FLT3 mutations [22%]), in which only 10% of patients achieved CR or CR …

… , FLT3 has been an important marker in different haematological malignancies, highlighting
in acute myeloid leukaemia, where FLT3 … The most common form of FLT3 mutation is an …