[HTML][HTML] FOXO1–FGFR1 fusion and amplification in a solid variant of alveolar rhabdomyosarcoma
J Liu, MA Guzman, D Pezanowski, D Patel… - Modern Pathology, 2011 - Elsevier
Rhabdomyosarcoma is the most common pediatric soft tissue malignancy. Two major
subtypes, alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma, constitute 20
and 60% of all cases, respectively. Approximately 80% of alveolar rhabdomyosarcoma carry
two signature chromosomal translocations, t (2; 13)(q35; q14) resulting in PAX3–FOXO1
fusion, and t (1; 13)(p36; q14) resulting in PAX7–FOXO1 fusion. Whether the remaining
cases are truly negative for gene fusion has been questioned. We are reporting the case of a …
subtypes, alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma, constitute 20
and 60% of all cases, respectively. Approximately 80% of alveolar rhabdomyosarcoma carry
two signature chromosomal translocations, t (2; 13)(q35; q14) resulting in PAX3–FOXO1
fusion, and t (1; 13)(p36; q14) resulting in PAX7–FOXO1 fusion. Whether the remaining
cases are truly negative for gene fusion has been questioned. We are reporting the case of a …
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