FTO intronic SNP strongly influences human neck adipocyte browning determined by tissue and PPARγ specific regulation: A transcriptome analysis

BB Tóth, R Arianti, A Shaw, A Vámos, Z Veréb… - Cells, 2020 - mdpi.com
… To learn more about human adipocyte browning and attempting to through more light on …
, we decided to study neck adipocyte populations derived from primary human adipose-derived …

Transcriptome analysis of browning human neck area adipocytes reveals strong influence by the FTO intronic SNP variant in addition to tissue and PPARγ specific …

BB Tóth, R Arianti, A Shaw, A Vámos, Z Veréb… - BioRxiv, 2020 - biorxiv.org
FTO intronic SNP strongly influences human neck adipocyte browning determined by tissue
and PPARγ specific regulation: … FTO intronic SNP strongly influences human neck adipocyte

Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue

J Ronkainen, TJ Huusko, R Soininen, E Mondini… - Scientific reports, 2015 - nature.com
… has been given to the characterization of FTO in fat tissue. … targeting the second intron of
mouse Fto gene, disrupting the … the association between human SNPs in the Fto and higher BMI …

Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo

S Laber, S Forcisi, L Bentley, J Petzold, F Moritz… - Science …, 2021 - science.org
… It has recently been shown that FTO intronic regions form … mouse adipose tissue (mostly
consisting of mature adipocytes) … , we established a chain of causation in human preadipocytes …

Role of Fto in the gene and microRNA expression of mouse adipose tissues in response to high-fat diet

J Ronkainen - 2016 - oulurepo.oulu.fi
… the effects of Fto on the miRNA regulation in WAT browning and … obesity-associated SNP
located in the first intron of FTO. Around … Furthermore, FTO may have a role in determination of …

[HTML][HTML] FTO gene polymorphisms at the crossroads of metabolic pathways of obesity and epigenetic influences

AM Popović, A Huđek Turković, K Žuna… - Food Technology and …, 2023 - hrcak.srce.hr
… in an intronic region of the FTO gene that is highly conserved … FTO gene expression in the
brain was also determined after … , implying that FTO expression is higher in adipose tissue

[PDF][PDF] Investigation of FTO gene-BMI association in a Romanian sample: A functional genomic interpretation

FI Lincă, L Alexandrescu, N Cucu… - … Res Appl Chem, 2023 - biointerfaceresearch.com
… of the FTO single nucleotide polymorphisms (SNPs): … Although GWAS results have
established that FTO intron 1 … other preferred tissue of FTO expression is the adipose tissue, …

Human abdominal subcutaneous-derived active beige adipocytes carrying FTO rs1421085 obesity-risk alleles exert lower thermogenic capacity

A Vámos, R Arianti, BÁ Vinnai, R Alrifai… - Frontiers in Cell and …, 2023 - frontiersin.org
… , an intronic rs1421085 T-to-C SNP has recently attracted … Flux of amino acids into or from
adipocytes was calculated by … can be found in cervical, supraclavicular, axillary, mediastinal…

FTO rs9939609 influence on adipose tissue localization in the Italian population

G Merra, P Gualtieri, G Cioccoloni, S Falco… - European review for …, 2020 - iris.uniroma1.it
… The FTO rs9939609 variant, located in the first intron of the … to confirm the association of the
SNP with obesity, using a … in humans FTO A allele is extremely specific for the FM, given that …

Identification and association of single nucleotide polymorphisms of the FTO gene with indicators of overweight and obesity in a young Mexican population

A Chama-Avilés, KL Flores-Viveros, JA Cabrera-Ayala… - Genes, 2023 - mdpi.com
… and determine associations between genetic variants of FTO … investigating adipocytes derived
from human adipose tissue, … of SNP rs1421085 promoted a greater darkening of fat cells […