FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively …

K Chiba, Y Yanagawa, Y Masubuchi… - The Journal of …, 1998 - journals.aai.org
… to PLN, MLN, and PP in rats was accelerated at 3 h after FTY720 … that FTY720 sequesters
circulating mature lymphocytes into PLN, MLN, and PP by acceleration of lymphocyte homing …

FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin …

Y Yanagawa, K Sugahara, H Kataoka… - The Journal of …, 1998 - journals.aai.org
FTY720-induced acceleration of lymphocyte homing and subsequent sequestration of
lymphocytes … to be related to the immunosuppressive activity of FTY720, since the integration and …

FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency …

YANAGAWA, MASUBUCHI, CHIBA - Immunology, 1998 - Wiley Online Library
… 1,2 FTY720 shows more potent immunosuppressive activity disappearance of circulating
lymphocytes in FTY720-… decreasing the circulating lymphocytes in the bloodstream, lymphocyte

FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation

V Brinkmann, D Pinschewer, K Chiba, L Feng - Trends in Pharmacological …, 2000 - cell.com
FTY720, a novel immunosuppressant, induces sequestration of circulating mature
lymphocytes by acceleration of lymphocyte homing in rats. I. …

Immunosuppressant FTY720 inhibits thymocyte emigration

H Yagi, R Kamba, K Chiba, H Soga… - European journal of …, 2000 - Wiley Online Library
circulation behavior of T lymphocytes; FTY720 has been shown to sequester circulating mature
lymphocytes … in circulation dynamics of lymphocytes induced by FTY720 prompted us to …

FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A

T Koshiba, B Van Damme, O Rutgeerts, M Waer… - …, 2003 - journals.lww.com
FTY720-induced lymphopenia is reversible on cessation of … effect of FTY720 and indicate
that lymphopenia persists as … lymphocyte function but also normal lymphocyte circulation are …

FTY720: altered lymphocyte traffic results in allograft protection

V Brinkmann, DD Pinschewer, L Feng, S Chen - Transplantation, 2001 - journals.lww.com
… The FTY720-induced sequestration of lymphocytes from the … of FTY720 seems to modulate
lymphocyte circulation without … FTY720, a novel immunosuppressant, induces sequestration

FTY720—the first compound of a new promising class of immunosuppressive drugs

U Kunzendorf, E Ziegler… - Nephrology Dialysis …, 2004 - academic.oup.com
… mice demonstrated that FTY720-induced lymphocyte sequestration in lymph nodes …
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes

FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate …

K Chiba - Pharmacology & therapeutics, 2005 - Elsevier
… the sequestration of circulating mature lymphocytes is presumed to be the main mechanism
of FTY720 immunosuppressive … Thus, FTY720 causes the sequestration of circulating mature

FTY720: from bench to bedside

BD Kahan - Transplantation proceedings, 2004 - Elsevier
… sinclairii, is a novel immunosuppressant that in experimental … abrogate drug-induced
lymphocyte sequestration. Sensitivity … , and mature DC, serving as the conduit to draw lymphocytes