… Pathological alterations of protein content can lead to … of an ALS-associated TDP-43
mutant in drosophila leads to … This rescued behavioral and memory deficits and exerted a …

… alterations and counteracting DNA repair strategies in ALS … an alternative strategy crucial for
the rescue of DNA integrity at … derived from the mutated ALS-associated C9ORF72 locus are …

… Many pathological processes are associated with ALS, including … FUS protein develops
insoluble aggregation in degenerated … of ALS patients, which is accelerated by ALS-linked FUS …

… been characterized by pathological changes in neuronal axons… (5) FUS-related mutations in
ALS lead to the accumulation of … able to rescue axonal growth defects in SMA motor neurons …

… ROS produced by ALSassociated protein aggregation impairs … due to protein overexpression
and positional changes … lower MNs, rescuing muscle atrophy and mitigating ALS disease …

… Interestingly, a series of ALS associated genes/proteins have … the nuclear protein complex,
the R521C and R521H changes … , but rescued FUS associated-DDR and neurodegeneration …

… FUS, and downregulating either protein partially rescues the … If it is proven that mitophagy
is the main altered MQC in ALS, … of different ALS-associated proteins identifies converging …

… emerged due to the very early pathological changes occurring at … carriers of known
ALS-associated mutations such as … astrocytes from ALS patients harboring the FUS mutation found …

… and personality changes, and similarly to ALS, can be … due to pathological, genetic and
clinical overlap (Neumann et … Further, aggregation of ALS-associated proteins leads to an …

… : its relative ease of genetic modification; genes implicated in … shows certain pathological
features similar to ALS, they also … motor function, which was rescued upon co-expression with …