Background: Decubitus is one of nosocomial infection that caused by a very long bedrest and physical immobilization. The prevalence of decubitus was still high in Indonesia. The objective of this systematic review was to identify factors that cause decubitus in patient with bedrest and physical immobilization. Method: 15 best articles were found using PECOT framework in some databases; EBSCO, Science Direct, Scopus, ProQuest, Pub Med, Wiley and Springer Link. Those articles have been chosen based on some criteria. Result: These are factors that cause decubitus; Medical diagnosis, nutritional deficit, using mechanical ventilator, skin integrity, age, gender, immobilization, skin type, nurse’s workload, Length of Stay (LOS), fecal incontinence, environment humidity, albumin, hemoglobin, limfosit, triceps skinfold, blood pressure, sensory perception, friction, weight, mental status, vertebra trauma, diabetic history, and hypertension. Discussion: The most dominant factor was immobilization, skin integrity, friction, nutrition, age, and gender.