Recently we reported that middle ear pressure (MEP), middle ear effusion (MEE), and
ossicular changes each contribute to the loss of tympanic membrane (TM) mobility in a
guinea pig model of acute otitis media (AOM) induced by Streptococcus pneumoniae (Guan
and Gan, 2013). However, it is not clear how those factors vary along the course of the
disease and whether those effects are reproducible in different species. In this study, a
chinchilla AOM model was produced by transbullar injection of Haemophilus influenzae …