Fas-induced caspase denitrosylation

JB Mannick, A Hausladen, L Liu, DT Hess, M Zeng… - Science, 1999 - science.org
… activity (8), probably because Fas alone had fully induced the denitrosylation of caspase
at … Fas-induced caspase-3 activation (14), consistent with our hypothesis that caspase-3 S-…

Fas ligand-induced apoptosis is regulated by nitric oxide through the inhibition of fas receptor clustering and the nitrosylation of protein kinase Cε

PR Dash, J McCormick, MJCB Thomson… - Experimental cell …, 2007 - Elsevier
… an important role in the regulation of Fas-induced apoptosis. … -caspase 8 to the DISC leads
to the activation of caspase 8 … unable to observe any rapid denitrosylation of PKCε (data not …

Activation and Denitrosylation of Procaspase-3 in KA-induced Excitotoxicity

Y Liu, H Yan, J Zhang, YT Cai, XH Yin… - Protein and Peptide …, 2023 - ingentaconnect.com
… ) -caspase-8 is shown to induce caspases-3 denitrosylation on … activate the procaspase-3
through denitrosylation and lead to … S-nitrosylation reaction with Cys 163 of Caspase3, [22]. In …

Neuroprotection of co-activation of GABA receptors by preventing caspase-3 denitrosylation in KA-induced seizures

XW Wei, H Yan, B Xu, YP Wu, C Li, GY Zhang - Brain Research Bulletin, 2012 - Elsevier
Fas-induced apoptosis, caspases are denitrosylated, allowing the catalytic site to function.
Fas activates caspase-3 not only by inducing the cleavage of the caspase … the denitrosylation

GluR6-FasL-Trx2 mediates denitrosylation and activation of procaspase-3 in cerebral ischemia/reperfusion in rats

N Sun, JR Hao, XY Li, XH Yin, YY Zong… - Cell death & …, 2013 - nature.com
denitrosylated and activated after I/R in rat hippocampus. NS102, a glutamate receptor 6 (GluR6)
antagonist, can inhibit the denitrosylation of … We also found that caspase-3 activation is …

… oxide prevents tumor necrosis factor α–induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8

YM Kim, TH Kim, HT Chung, RV Talanian, XM Yin… - Hepatology, 2000 - Elsevier
caspases including caspase-3. We examined the effect of NO on cytochrome c release and
caspase-9 and caspase-3 … Bid-deficient mice are resistant to Fas-induced hepatocellular …

Melanoma differentiation associated gene-7/interleukin-24 induces caspase-3 denitrosylation to facilitate the activation of cancer cell apoptosis

H Tian, DF Zhang, BF Zhang, HZ Li… - Journal of Interferon & …, 2015 - liebertpub.com
… relationship between caspase-3 denitrosylation and … caspase-3 denitrosylation through
its dithiol moiety (Ic), suggesting that Fas-induced TrxR2 enhancement is implicated in caspase

[HTML][HTML] Sensitivity to anti-Fas is independent of increased cathepsin D activity and adrenodoxin reductase expression occurring in NOS-3 overexpressing HepG2 …

CI Linares, G Ferrín, P Aguilar-Melero… - … et Biophysica Acta (BBA …, 2015 - Elsevier
… to anti-Fas induced cell death, independently of AR expression and CatD activity. … anti-Fas-induced
cell death, which was mediated by the activity increase of caspase-9 and caspase-3. …

Nitric oxide protects cultured rheumatoid synovial cells from Fasinduced apoptosis by inhibiting caspase‐3

K Migita, S Yamasaki, M Kita, H Ida, K Shibatomi… - …, 2001 - Wiley Online Library
… in NO-mediated blockage between caspase-3 and caspase-8. In addition to protein
nitrosylation, a denitrosylation system is also involved in caspase activation. Moreover, it is also …

Edaravone inhibits procaspase‐3 denitrosylation and activation through FasL‐Trx2 pathway in KA‐induced seizure

L Hao, L Dong, Q Yu, W Shen… - Fundamental & Clinical …, 2020 - Wiley Online Library
… can be denitrosylated and subsequently activated by Trx2 after during Fas-induced apoptosis.
… mediated by the Trx-TrxR system and that preventing caspase-3 denitrosylation exerts the …