In this study, a combined method of the finite element analysis (FEA) and the multi-body dynamic simulation (MDS) was proposed to estimate the fatigue life of bogie frame of railway covered goods wagons. The multi-body dynamic (MBD) model of the wagon was built with the bogie frame body could be converted from the modal neutral file of FE model, which is obtained by using the ANSYS–ADAMS interface feature. The dynamic loads were obtained from the results of the MDS before being served as inputs in the structural dynamic analysis of bogie frame. From the results of structural dynamic analysis, the stress histories were determined and then used in the fatigue life analysis. The fatigue analysis model of the bogie frame was established based on the stress-life method. In addition, the effects of percentage probability of survival and reduction coefficient of material strength of were considered. The fatigue life of the bogie frame was estimated, then evaluated according to QCVN 87:2015/BGTVT.