The acquisition and expression of conditioned fear depends on prefrontal-amygdala circuits.
Auditory fear conditioning increases the tone responses of lateral amygdala neurons, but the
increase is transient, lasting only a few hundred milliseconds after tone onset. It was recently
reported that that the prelimbic (PL) prefrontal cortex transforms transient lateral amygdala
input into a sustained PL output, which could drive fear responses via projections to the
lateral division of basal amygdala (BL). To explore the possible mechanisms involved in this …

F, Quirk GJ, Nair SS. Fear signaling in the prelimbic-amygdala circuit: a computational
modeling and recording study. J Neurophysiol 110: 844–861, 2013. First published May 22,
2013; doi: 10.1152/jn. 00961.2012.—The acquisition and expression of conditioned fear
depends on prefrontal-amygdala circuits. Auditory fear conditioning increases the tone
responses of lateral amygdala neurons, but the increase is transient, lasting only a few
hundred milliseconds after tone onset. It was recently reported that that the prelimbic (PL) …