[PDF][PDF] Feasibility of Water Therapy for Slowing Autosomal Dominant Polycystic Kidney Disease Progression
Background In animal models of ADPKD, high water intake (HWI) decreases vasopressin
secretion and slows disease progression, but the efficacy of HWI in human ADPKD is
uncertain. Methods This exploratory, prospective, crossover study of ADPKD subjects (n= 7)
evaluated the hypothesis that HWI slows the rate of increase in height-adjusted total kidney
volume (ht-TKV; a biomarker for ADPKD progression) and reduces pain. Subjects at high
risk of ADPKD progression (ie, Mayo Imaging Classifications 1C/1D) were evaluated during …
secretion and slows disease progression, but the efficacy of HWI in human ADPKD is
uncertain. Methods This exploratory, prospective, crossover study of ADPKD subjects (n= 7)
evaluated the hypothesis that HWI slows the rate of increase in height-adjusted total kidney
volume (ht-TKV; a biomarker for ADPKD progression) and reduces pain. Subjects at high
risk of ADPKD progression (ie, Mayo Imaging Classifications 1C/1D) were evaluated during …
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