Ferulic acid with ascorbic acid synergistically extenuates the mitochondrial dysfunction during β-adrenergic catecholamine induced cardiotoxicity in rats
SK Yogeeta, HRB Raghavendran… - Chemico-biological …, 2006 - Elsevier
Disruption of mitochondria and free radical mediated tissue injury have been reported
during cardiotoxicity induced by isoproterenol (ISO), a β-adrenergic catecholamine. The
present study was designed to investigate the effect of the combination of ferulic acid (FA)
and ascorbic acid (AA) on the mitochondrial damage in ISO induced cardiotoxicity. Induction
of rats with ISO (150mg/kgb. wt., ip) for 2 days resulted in a significant decrease in the
activities of respiratory chain enzymes (NADH dehydrogenase and cytochrome c-oxidase) …
during cardiotoxicity induced by isoproterenol (ISO), a β-adrenergic catecholamine. The
present study was designed to investigate the effect of the combination of ferulic acid (FA)
and ascorbic acid (AA) on the mitochondrial damage in ISO induced cardiotoxicity. Induction
of rats with ISO (150mg/kgb. wt., ip) for 2 days resulted in a significant decrease in the
activities of respiratory chain enzymes (NADH dehydrogenase and cytochrome c-oxidase) …
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