Fisetin imparts neuroprotection in experimental diabetic neuropathy by modulating Nrf2 and NF-κB pathways
The current study is aimed to assess the therapeutic potential of fisetin, a phytoflavonoid in
streptozotocin (STZ)-induced experimental diabetic neuropathy (DN) in rats. Fisetin was
administered (5 and 10 mg/kg) for 2 weeks (7th and 8th week) post STZ administration.
Thermal and mechanical hyperalgesia were assessed by measuring tactile sensitivity to
thermal and mechanical stimuli, respectively. Motor nerve conduction velocity (MNCV) was
determined using power lab system and sciatic nerve blood flow (NBF) was determined …
streptozotocin (STZ)-induced experimental diabetic neuropathy (DN) in rats. Fisetin was
administered (5 and 10 mg/kg) for 2 weeks (7th and 8th week) post STZ administration.
Thermal and mechanical hyperalgesia were assessed by measuring tactile sensitivity to
thermal and mechanical stimuli, respectively. Motor nerve conduction velocity (MNCV) was
determined using power lab system and sciatic nerve blood flow (NBF) was determined …
Fisetin imparts neuroprotection in experimental diabetic neuropathy by modulating Nrf2 and NF-κB pathways.
RS Reddemma Sandireddy, VG Yerra… - 2016 - cabidigitallibrary.org
The current study is aimed to assess the therapeutic potential of fisetin, a phytoflavonoid in
streptozotocin (STZ)-induced experimental diabetic neuropathy (DN) in rats. Fisetin was
administered (5 and 10 mg/kg) for 2 weeks (7th and 8th week) post STZ administration.
Thermal and mechanical hyperalgesia were assessed by measuring tactile sensitivity to
thermal and mechanical stimuli, respectively. Motor nerve conduction velocity (MNCV) was
determined using power lab system and sciatic nerve blood flow (NBF) was determined …
streptozotocin (STZ)-induced experimental diabetic neuropathy (DN) in rats. Fisetin was
administered (5 and 10 mg/kg) for 2 weeks (7th and 8th week) post STZ administration.
Thermal and mechanical hyperalgesia were assessed by measuring tactile sensitivity to
thermal and mechanical stimuli, respectively. Motor nerve conduction velocity (MNCV) was
determined using power lab system and sciatic nerve blood flow (NBF) was determined …
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