This paper summarize a three years (2001-2003; July-September) fish survey and put in relation these results to natural and human factors that affect these lotic systems ichthyofauna. The presence and structure of fish assemblages were related to human influences (urban, industrial, hydro technical and land-use activities) to provide a picture of the fish fauna habitats quality across the Târnava rivers watershed. Mapping out the ichthyologic component as an element of the river continuum allow assertions concerning fish assemblages structure variation along the last few decades and cause-effect relations identification as an important informational element in the construction of a needed integrated management plan for the whole Târnava rivers lotic systems.