Flow-cytometric analysis of reactive oxygen species in cancer cells under treatment with brassinosteroids
PA Kisselev, OV Panibrat, AR Sysa, MV Anisovich… - Steroids, 2017 - Elsevier
To explore the underlying mechanism of cancer cell growth inhibition by brassinosteroids
(BS), reactive oxygen species (ROS) generation under treatment with 28-homocastasterone
and its synthetic derivatives (22 S, 23S)-28-homocastasterone was measured in A549
human lung adenocarcinoma cells. BS induced ROS generation in A549 cells and their
growth in a time and dose-dependent manner. The maximal effect was observed for (22S,
23S)-28-homocastasterone which at 30 μM concentration showed a 6-fold increase of ROS …
(BS), reactive oxygen species (ROS) generation under treatment with 28-homocastasterone
and its synthetic derivatives (22 S, 23S)-28-homocastasterone was measured in A549
human lung adenocarcinoma cells. BS induced ROS generation in A549 cells and their
growth in a time and dose-dependent manner. The maximal effect was observed for (22S,
23S)-28-homocastasterone which at 30 μM concentration showed a 6-fold increase of ROS …
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