Annona is a genus belongs to Annonaceae family, consisting of numerous species that produce edible fruit. Four species namely A. glabra, A. montana, A. muricata and A. squamosa collections of Purwodadi Botanic Garden were recorded for its flowering and fruiting times, since November 2010 to April 2013. The data were scored and complemented with climate data (temperature, rainfall intensity, humidity) then analyzed using multiple linear regression analysis. The result showed that humidity was the most affected climate factors on the flowering and fruiting times of those species. Specifically, rainfall intensity (0-550 mm) affected to Annona muricata, temperature (25, 56-28, 33 C) and humidity (66, 83-85, 02%) to Annona squamosa, and humidity to A. glabra (71, 62-85, 02%) and A. montana (71, 62 to 82, 94%) as well. Flowering time of A. glabra occurs three times a year in wet and dry, and fruiting occurs twice a year in the same month. Annona muricata is flowering throughout the year and fruiting twice a year in wet. A. montana and A. squamosa recorded one a year during the wet month.