… The first FLT3 mutations to be identified were … , as FLT3 mutations are clearly secondary
abnormalities in at least some patients and are often restricted to a subpopulation of leukaemic …

… , FLT3 has been an important marker in different haematological malignancies, highlighting
in acute myeloid leukaemia, where FLT3 mutations … The most common form of FLT3 mutation …

… Mutations of FLT3 have been detected in about 30% of patients with acute myelogenous …
Patients with FLT3 mutations tend to have a poor prognosis. The mutations most often involve …

… juxtamembrane domain or mutations in the activating loop of FLT3. FLT3 mutations occur in
a … FLT3 mutations confer a poor prognosis in most retrospective studies. The consequence of …

… FLT3 but do not carry FLT3 mutations, have the same sensitivity to a potent FLT3 inhibitor as
leukemia cells with FLT3 mutations [… FLT3 gene is found in acute lymphoblastic leukaemia …

… FLT3 inhibitors 4,5 , suggests that FLT3-ITD probably represents a passenger lesion. Here
we report point mutations at three residues within the kinase domain of FLT3… inhibitor of FLT3, …

… Likewise, a lesser portion of chronic myelogenous leukemia (CML) blast crisis, as well as
chronic lymphocytic leukemia (CLL) and even T-cell ALL cells have been shown to express …

… with an FLT3 mutation center around the interpretation of FLT3 mutation test results and
around the decisions on the best induction and consolidation therapy. In addition, FLT3 TKIs are …

… FLT3/ALM and FLT3/ITD at varying ITD-ARs was determined and compared with those without
FLT3 mutations (FLT3/… Constitutive activation of FLT3 in acute myeloid leukaemia and its …

… for combining FLT3 inhibitors … FLT3 mutations in AML, clinical classification of the disease,
recent progress with next-generation FLT3 inhibitors, and mechanisms of resistance to FLT3 …