Fluorogenic gemcitabine based light up sensor for serum albumin detection in complex biological matrices
Colloids and Surfaces B: Biointerfaces, 2022•Elsevier
Herein we report fluorogenic derivative of gemcitabine (GEM-DNS), synthesized from
gemcitabine hydrochloride and dansyl chloride in a single step. Owing to its large stoke shift
of∼ 200 nm and intriguing photophysical properties, the said dye has been utilized to
estimate albumin concentration in complex bio-media such as human urine and blood
serum. High sensitivity and selectivity towards albumin make the aforementioned dye a
powerful diagnostic tool to detect ailments such as liver cirrhosis, diabetes, hypertension etc.
gemcitabine hydrochloride and dansyl chloride in a single step. Owing to its large stoke shift
of∼ 200 nm and intriguing photophysical properties, the said dye has been utilized to
estimate albumin concentration in complex bio-media such as human urine and blood
serum. High sensitivity and selectivity towards albumin make the aforementioned dye a
powerful diagnostic tool to detect ailments such as liver cirrhosis, diabetes, hypertension etc.
Abstract
Herein we report fluorogenic derivative of gemcitabine (GEM-DNS), synthesized from gemcitabine hydrochloride and dansyl chloride in a single step. Owing to its large stoke shift of ∼200 nm and intriguing photophysical properties, the said dye has been utilized to estimate albumin concentration in complex bio-media such as human urine and blood serum. High sensitivity and selectivity towards albumin make the aforementioned dye a powerful diagnostic tool to detect ailments such as liver cirrhosis, diabetes, hypertension etc.
Elsevier
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