Folic acid and the prevention of birth defects: 30 years of opportunity and controversies
KS Crider, YP Qi, LF Yeung, CT Mai… - Annual review of …, 2022 - annualreviews.org
For three decades, the US Public Health Service has recommended that all persons capable
of becoming pregnant consume 400 μg/day of folic acid (FA) to prevent neural tube defects
(NTDs). The neural tube forms by 28 days after conception. Fortification can be an effective
NTD prevention strategy in populations with limited access to folic acid foods and/or
supplements. This review describes the status of mandatory FA fortification among countries
that fortify (n= 71) and the research describing the impact of those programs on NTD rates …
of becoming pregnant consume 400 μg/day of folic acid (FA) to prevent neural tube defects
(NTDs). The neural tube forms by 28 days after conception. Fortification can be an effective
NTD prevention strategy in populations with limited access to folic acid foods and/or
supplements. This review describes the status of mandatory FA fortification among countries
that fortify (n= 71) and the research describing the impact of those programs on NTD rates …
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