Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum …

PG Cadena, MRS Cadena, S Sarmah, JA Marrs - Reproductive Toxicology, 2020 - Elsevier
The objective of this work was to determine whether folic acid (FA) reduces the embryonic
ethanol (EtOH) exposure induced behavioral and morphological defects in our zebrafish
fetal alcohol spectrum disorder (FASD) model. Teratogenic effects, mortality, the excitatory
light-dark locomotion (ELD), sleep (SL), thigmotaxis (TH), touch sensitivity (TS), and
optomotor response (OMR) tests were evaluated in larvae (6–7 days post-fertilization) using
four treatment conditions: Untreated, FA, EtOH and EtOH+ FA. FA reduced morphological …
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