Reductive alkylation of 5-methoxy-1-tetralone (6) with 2,3-dibromopropene gave an equilibrium
mixture of bicyclic diones 7 (51%) and 8 (35%). Radical cyclization of 7 afforded tricyclic …

… In summary, we have established a stereocontrolled synthesis of the platensimycin core
2 with the following key findings. (1) Diastereoselective Diels−Alder reaction proceeded …

… Finally, formation of the tetrahydrofuran moiety and oxidative deprotection of the enone
completed the racemic formal synthesis. The need of several protecting group operations makes …

… synthesis efforts, to ensure that the cycloisomerization of ester-capped alkyne 32 would lead
to a total synthesis of platensimycin [… the formal asymmetric total synthesis of platensimycin [(…

… synthesis of the oxatetracyclic core of (−)-platensimycin … synthesis of platensimycin.
Herein, we report a detailed account of our studies leading to the total synthesis of (−)-platensimycin…

The secondary metabolites platensimycin and platencin, isolated from the bacterial strain …
Platencin, though structurally similar to platensimycin, has been found to operate through a …

… Possible late-stage interconversion of the platensimycin core into the platencin system. …
at their synthesis. Since platensimycin was first described in 2006, 10 total or formal total …

… Because of the biological activity and structural novelty, we undertook the total synthesis
of platensimycin, first in racemic form. Platensimycin consists of an unusual 3amino-2,4-…

… technology was demonstrated by a formal total synthesis of (−)-platensimycin (18,
Scheme 3) from 14, an intermediate previously employed in our synthesis of (±)-platensimycin.[9a] …

… , haouamine A, platensimycin and platencin were investigated. … In the studies of platensimycin
and platencin, we intended to … accomplished the concise total synthesis of platencin from …