Formation of DNA: RNA Hybrid G‐Quadruplexes of Two G‐Quartet Layers in Transcription: Expansion of the Prevalence and Diversity of G‐Quadruplexes in Genomes

S Xiao, J Zhang, J Wu, R Wu, Y Xia… - Angewandte …, 2014 - Wiley Online Library
G‐quadruplexes are implicated in important cellular processes. Previous studies mostly
focused on intramolecular G‐quadruplexes of three or more G‐quartets. Those composed of
two G‐quartets were only shown to form in single‐stranded oligonucleotides. On the basis of
electrophoresis, DMS footprinting, fluorescence labeling, and photo‐cross‐linking, we
detected the formation of DNA: RNA hybrid G‐quadruplexes (HQs) of two G‐quartets during
the transcription of DNA duplexes. These HQs have a lifetime on the minute scale and are …

[PDF][PDF] Formation of DNA: RNA Hybrid G-Quadruplexes of Two G-Quartet Layers in Transcription: Expansion of the Prevalence and Diversity of G-Quadruplexes in …

肖姗, 张佳宇, 吴壬乙, 夏椰, 郑克威, 郝玉华, 谭铮 - 2014 - ir.ioz.ac.cn
G-quadruplexes are implicated in important cellular processes. Previous studies mostly
focused on intramolecular G-quadruplexes of three or more G-quartets. Those composed of
two G-quartets were only shown to form in single-stranded oligonucleotides. On the basis of
electrophoresis, DMS footprinting, fluorescence labeling, and photo-cross-linking, we
detected the formation of DNA: RNA hybrid G-quadruplexes (HQs) of two G-quartets during
the transcription of DNA duplexes. These HQs have a lifetime on the minute scale and are …
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