The global need for effective and safe alternative options for the prevention and treatment of diseases in the oral cavity stems from the increased incidence of disease, increased resistance of periodontopathogenic bacteria to antibiotics currently used, and economic considerations in developing countries [1-4].

Despite the diversity of pharmacological products, they can alter the microbiome of the oral cavity. They can cause unwanted side effects, such as diarrhea, vomiting or tooth pigmentation, sometimes toxic [5-7]. A study by Bidault et al. documented bacterial resistance to routine antibiotics (penicillin, cephalosporins, erythromycin, metronidazole) prescribed in treating oral infections [8]. These aspects support the continuous identification of alternative, natural phytotherapeutic drugs isolated from plants used in traditional medicine to replace synthetic chemicals [9, 10]. Herbal extracts have been used for medicinal purposes since ancient times. Researchers are becoming increasingly interested in natural chemicals, essential oils and plant extracts because of their antioxidant characteristics and benefits for human health [11, 12].