[PDF][PDF] Formulation and evaluation of an oral floating tablet of cephalexin
The objective of this study was to formulate an oral floating tablet of cephalexin (CEF) using
the hydrophilic polymer 2 hydroxy propyl methyl cellulose (HPMC), gas generating agent
sodium bicarbonate and citric acid. A 3 factorial design was applied systematically; the
amount of citric acid (X1) and amount of HPMC K100M (X2) were selected as independent
variables. The time required for 50% drug release (t), percentage drug release at 12hr (Q)
and
the hydrophilic polymer 2 hydroxy propyl methyl cellulose (HPMC), gas generating agent
sodium bicarbonate and citric acid. A 3 factorial design was applied systematically; the
amount of citric acid (X1) and amount of HPMC K100M (X2) were selected as independent
variables. The time required for 50% drug release (t), percentage drug release at 12hr (Q)
and
Abstract
The objective of this study was to formulate an oral floating tablet of cephalexin (CEF) using the hydrophilic polymer 2 hydroxy propyl methyl cellulose (HPMC), gas generating agent sodium bicarbonate and citric acid. A 3 factorial design was applied systematically; the amount of citric acid (X1) and amount of HPMC K100M (X2) were selected as independent variables. The time required for 50% drug release (t), percentage drug release at 12hr (Q) and
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