Formulation of rivastigmine niosomes for alzheimer disease

MAR Estabragh, Z Hamidifar… - International Pharmacy …, 2018 - journals.sbmu.ac.ir
Introduction: Alzheimer is a brain dysfunctional disease which could destroy the cognition
and learning capabilities of the patient. Rivastigmine is an acetylcholine esterase inhibitor
which can improve brain function in both Alzheimer and Parkinson's diseases. Hereby, we
prepared niosomal formulations of rivastigmine for better penetration of this drug to brain.
Methods and Results: Sorbitan esters (Span 20, 40, 60 and 80), their water-soluble
derivatives (Tween 20, 40, 60 and 80) and cholesterol were used for preparation of …
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