Formulation optimization and in-vitro evaluation of oral floating captopril matrix tablets using factorial design
Purpose: To develop a zero-order sustained release floating formulation of captopril, and
optimize its drug release for enhanced oral bioavailability. Methods: A relatively new
approach, 3 2 full factorial design, was used to formulate floating captopril matrix tablets and
to systematically optimize its drug release using varying levels of xanthan gum and
hydroxypropyl methylcellulose (HPMC) K100M polymers. Calcium carbonate was used as
gasgenerating agent. After setting the levels by preliminary trials, nine tablet formulations …
optimize its drug release for enhanced oral bioavailability. Methods: A relatively new
approach, 3 2 full factorial design, was used to formulate floating captopril matrix tablets and
to systematically optimize its drug release using varying levels of xanthan gum and
hydroxypropyl methylcellulose (HPMC) K100M polymers. Calcium carbonate was used as
gasgenerating agent. After setting the levels by preliminary trials, nine tablet formulations …
Formulation optimization and in-vitro evaluation of oral floating captopril matrix tablets using factorial design.
MA Muhammad Ahsan, NA Nasir Abbas… - 2015 - cabidigitallibrary.org
Purpose: To develop a zero-order sustained release floating formulation of captopril, and
optimize its drug release for enhanced oral bioavailability. Methods: A relatively new
approach, 32 full factorial design, was used to formulate floating captopril matrix tablets and
to systematically optimize its drug release using varying levels of xanthan gum and
hydroxypropyl methylcellulose (HPMC) K100 M polymers. Calcium carbonate was used as
gas-generating agent. After setting the levels by preliminary trials, nine tablet formulations …
optimize its drug release for enhanced oral bioavailability. Methods: A relatively new
approach, 32 full factorial design, was used to formulate floating captopril matrix tablets and
to systematically optimize its drug release using varying levels of xanthan gum and
hydroxypropyl methylcellulose (HPMC) K100 M polymers. Calcium carbonate was used as
gas-generating agent. After setting the levels by preliminary trials, nine tablet formulations …
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