Foxp3+ Tregs from Langerhans cell histiocytosis lesions co-express CD56 and have a definitively regulatory capacity
J Mitchell, J Kelly, E Kvedaraite… - Clinical …, 2020 - Elsevier
Langerhans cell histiocytosis (LCH) lesions contain myeloid lineage 'LCH'cells. Regulatory
T cells (Tregs) are also enriched within lesions, although their role in LCH pathogenesis is
unknown. LCH cells are thought to produce the transforming growth factor beta (TGF-β)
within lesions, however whether Tregs contribute is unestablished. Using flow cytometry, we
analyzed relative frequencies of live Tregs from LCH patients and identified CD56
expression and TGF-β production by lesion Tregs. While CD56+ Tregs were enriched in …
T cells (Tregs) are also enriched within lesions, although their role in LCH pathogenesis is
unknown. LCH cells are thought to produce the transforming growth factor beta (TGF-β)
within lesions, however whether Tregs contribute is unestablished. Using flow cytometry, we
analyzed relative frequencies of live Tregs from LCH patients and identified CD56
expression and TGF-β production by lesion Tregs. While CD56+ Tregs were enriched in …
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