Inflammation inevitably follows injury of various tissues, including bone. Transgenic
overexpression of Fra‐1, a component of the transcription factor activator protein‐1 (AP‐1),
in various tissues progressively and globally enhances bone formation, but little is known
about the possible effects of Fra‐1/AP‐1 on fracture healing. We created a transverse
fracture of the mouse tibial diaphysis and examined fracture healing radiologically,
histologically, and immunologically. Strikingly, fracture union was delayed even though the …

CiNii 博士論文 - Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture
healing … Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture
healing Fra-1/AP-1は骨折治癒過程における炎症反応と軟骨形成を抑制する … Fra-1/AP-1は
骨折治癒過程における炎症反応と軟骨形成を抑制する …