From the sequence to the superstructural properties of DNAs

C Anselmi, P De Santis, R Paparcone, M Savino… - Biophysical …, 2002 - Elsevier
A theoretical model for predicting intrinsic and induced DNA superstructures as well as their
thermodynamic properties is presented. Intrinsic sequence-dependent superstructures are
evaluated by integrating local deviations from the canonical B-DNA of the different
dinucleotide steps. Induced superstructures are obtained by adopting the principle of
minimum deformation free energy, evaluated in the Fourier space, in the framework of first-
order elasticity. Finally dinucleotide stacking energies and melting temperatures are …
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