[HTML][HTML] Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles
High performance liquid chromatographic method was optimized, developed and validated
as per the ICH guidelines. In this study the 20 mM ammonium formate and acetonitrile in the
57: 43 ratio were used as mobile phase for the analysis of valsartan. Full factorial design
was used to optimize the effect of variable factors. The responses were peak area, tailing
factor and number of theoretical plates. The quadratic effect of flow rate and wavelength
individually as well as in interaction were most significant (p< 0.0001 and p< 0.0086 …
as per the ICH guidelines. In this study the 20 mM ammonium formate and acetonitrile in the
57: 43 ratio were used as mobile phase for the analysis of valsartan. Full factorial design
was used to optimize the effect of variable factors. The responses were peak area, tailing
factor and number of theoretical plates. The quadratic effect of flow rate and wavelength
individually as well as in interaction were most significant (p< 0.0001 and p< 0.0086 …
以上显示的是最相近的搜索结果。 查看全部搜索结果