Functional dissection of the HIV-1 Rev trans-activator—derivation of a trans-dominant repressor of Rev function
MH Malim, S Böhnlein, J Hauber, BR Cullen - Cell, 1989 - Elsevier
Human immunodeficiency virus type 1 (HIV-1) encodes a nuclear trans-activator, termed
Rev, that is required for the expression of the viral structural proteins and, hence, for viral
replication. The Rev protein acts posttranscriptionally to induce the sequence-specific
nuclear export of unspliced HIV-1 mRNA species that are otherwise excluded from the cell
cytoplasm. We have used site-directed mutagenesis to identify two distinct regions of the HIV-
1 Rev protein that are required for in vivo biological activity. The larger and more N-terminal …
Rev, that is required for the expression of the viral structural proteins and, hence, for viral
replication. The Rev protein acts posttranscriptionally to induce the sequence-specific
nuclear export of unspliced HIV-1 mRNA species that are otherwise excluded from the cell
cytoplasm. We have used site-directed mutagenesis to identify two distinct regions of the HIV-
1 Rev protein that are required for in vivo biological activity. The larger and more N-terminal …
[引用][C] Functional dissociation of the HIV-1 Rev trans-activator: derivation of a trans-dominant repressor of Rev function
M MH - Cell, 1989 - cir.nii.ac.jp
Functional dissociation of the HIV-1 Rev trans-activator : derivation of a trans-dominant
repressor of Rev function | CiNii Research … Functional dissociation of the HIV-1 Rev trans-activator
: derivation of a trans-dominant repressor of Rev function …
repressor of Rev function | CiNii Research … Functional dissociation of the HIV-1 Rev trans-activator
: derivation of a trans-dominant repressor of Rev function …
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