Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
To direct human embryonic stem (HES) cells to a dopaminergic neuronal fate, we cocultured
HES cells that were exposed to both sonic hedgehog and fibroblast growth factor 8 with
telomerase-immortalized human fetal midbrain astrocytes. These astrocytes substantially
potentiated dopaminergic neurogenesis by both WA09 and WA01 HES cells, biasing them
to the A9 nigrostriatal phenotype. When transplanted into the neostriata of 6-
hydroxydopamine–lesioned parkinsonian rats, the dopaminergic implants yielded a …
HES cells that were exposed to both sonic hedgehog and fibroblast growth factor 8 with
telomerase-immortalized human fetal midbrain astrocytes. These astrocytes substantially
potentiated dopaminergic neurogenesis by both WA09 and WA01 HES cells, biasing them
to the A9 nigrostriatal phenotype. When transplanted into the neostriata of 6-
hydroxydopamine–lesioned parkinsonian rats, the dopaminergic implants yielded a …
[引用][C] Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.
高橋淳 - Neurological Surgery 脳神経外科, 2007 - cir.nii.ac.jp
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by
coculture with telomerase-immortalized midbrain astrocytes. | CiNii Research … Functional
engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with
telomerase-immortalized midbrain astrocytes. …
coculture with telomerase-immortalized midbrain astrocytes. | CiNii Research … Functional
engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with
telomerase-immortalized midbrain astrocytes. …