Ichnoviruses belong to the virus family Polydnaviridae, whose members are obligately associated with certain endoparasitoid wasps. Expression of ichnovirus genes in parasitized lepidopteran hosts leads to immune suppression and is essential for successful parasitization. To date, the role of specific ichnovirus genes in alteration of host physiology has been unclear, and no cellular homologues have been described. Here, we describe the isolation of a gene family from two ichnoviruses that is homologous to the innexin gene family, which encodes gap junctions in invertebrates.