Anti-ectoparasite vaccines offer attractive alternatives to the use of chemical pesticides,
especially if they also control the pathogens that ectoparasites transmit. However, selection
of suitable antigens is a major constraint on vaccine development. The recombinant tick
cement protein, 64TRP, derived from the African brown ear tick, Rhipicephalus
appendiculatus, acts as a transmission-blocking vaccine in a mouse model of tick-borne
encephalitis virus (TBEV) transmission, protecting immunised mice against lethal challenge …