Laser powder bed fusion (LPBF) provides fine spatial resolution for additively manufactured (AM) objects. Development of a new LPBF machine technology enables the incorporation of multi-directional compositional gradients. A sample with six compositional regions ranging from 100% titanium to 100% tantalum perpendicular to the build direction was produced, while also changing the processing parameters for the different material composition. Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) were used to observe both the bulk and interface regions. SEM images demonstrate that dendritic morphology is present as a result of the non-equilibrium solidification instead of the one-phase solid solution predicted from the equilibrium phase diagram. EDS line and area scans indicate diffusional segregation of tantalum away from the interface regions. The ability to functionally grade material composition in multiple directions using LPBF AM provides the capability to fabricate complex geometries with spatially varying properties tailored to the desired application.