Mutants defective in meiotic recombination were isolated using a disomic haploid strain of S.
cerevisiae, and were classified into 11 genes. Two, MRE2 and MRE11, are new genes and
nine are previously identified genes. The mre2 and mrell deletion mutants are proficient in
mitotic recombination, but are defective in meiotic recombination and in formation of viable
spores. The spore inviability, however, is alleviated by an additional mutation, spo13, which
bypasses meiosis I. In addition, neither meiosis specific DSBs at recombination hot-spots …