G protein-coupled receptor kinase 2 (GRK2) promotes breast tumorigenesis through a HDAC6-Pin1 axis

L Nogués, C Reglero, V Rivas, A Salcedo, V Lafarga… - …, 2016 - thelancet.com
… We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast cancer.
… Besides its canonical role in the desensitization of G protein-coupled receptors (GPCR) ( …

[PDF][PDF] G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis

D Hardisson, F Mayor Jr, P Penela - 2016 - researchgate.net
… We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast
Developmental and tumoral vascularization is regulated by G proteincoupled receptor kinase 2. …

G-proteincoupled receptor kinase 2 as a potential modulator of the hallmarks of cancer

L Nogués, C Reglero, V Rivas, M Neves, P Penela… - Molecular …, 2017 - Elsevier
G-proteincoupled receptor kinase 2 (GRK2) is arising as one of such … GRK2 levels are
starting to be reported in different tumoral contexts and shown to promote breast tumorigenesis

[PDF][PDF] G protein-coupled receptor kinase 2 (GRK2) as a potential modulator of the hallmarks of cancer

L Nogués, C Reglero, V Rivas, M Neves… - Molecular …, 2016 - researchgate.net
… contexts and shown to promote breast tumorigenesis or to trigger … In this context, Gprotein-coupled
receptor kinase2 (GRK2) is … that the GRK2-HDAC6-Pin1 molecular signature in breast

G protein-coupled receptor kinases (GRKs) in tumorigenesis and cancer progression: GPCR regulators and signaling hubs

L Nogues, J Palacios-Garcia, C Reglero… - Seminars in Cancer …, 2018 - Elsevier
… both G protein-coupled receptors (GPCR) and growth factor … , the switch-on of the
GRK2-HDAC6-Pin1 axis emerges as a … in GRK2 and GRK3 may cooperate in promoting aberrant …

GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis

WK Wang, HY Lin, CH Lin, HH Lee, YL Chen… - Breast Cancer …, 2024 - Springer
… /protein expression and prognostic significance of G proteincoupled receptor kinase 6 (GRK6)
in … GRK2 and GRK4, not GRK3, upregulation have been found to promote tumorigenesis, …

G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub

P Penela, C Ribas, F Sánchez-Madrid… - Cellular and Molecular …, 2019 - Springer
… indicates that G protein-coupled receptor kinase 2 (GRK2) is a … G protein-coupled receptor
(GPCR) signaling and also via … domain also enhances the interactions of GRK2 with other …

GRK6 promotes triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis

WK Wang, HY Lin, CH Lin, HH Lee, YL Chen, YHK Lin… - 2024 - researchsquare.com
… expression and prognostic significance of G proteincoupled receptor kinase 6 (GRK6) in BC
… though GRK2, GRK3 and GRK4 upregulation have been found to promote tumorigenesis, …

[HTML][HTML] Pin1 is involved in HDAC6-mediated cancer cell motility

HH Chuang, MS Huang, PH Wang, YP Liu… - … journal of medical …, 2018 - ncbi.nlm.nih.gov
… the multifunctional roles of Pin1 in tumorigenesis and cancer progression. … documented that
protein kinases, such as Aurora A, CK2, EGFR, ERK, GRK2, GSK3β, … CK2 casein kinase 2

The role of G protein-coupled receptor kinases in the pathology of malignant tumors

W Sun, J Wu, W Peng, J Sun, W Wei - Acta Pharmacologica Sinica, 2018 - nature.com
… of GRK2 in breast tumorigenesis. Elevated GRK2 protein levels are observed in breast cancer
… The activation of GRK2-HDAC6-Pin1 signaling helps trigger a self-perpetuating positive …