GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical
atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here,
we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128
individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel
susceptibility loci for cIMT, one independent association at the previously-identified PINX1
locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular …
atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here,
we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128
individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel
susceptibility loci for cIMT, one independent association at the previously-identified PINX1
locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular …
[引用][C] GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun 2018; 9: 5141
N Franceschini, C Giambartolomei, PS de Vries… - … org/10.1038/s41467-018-07340-5 …
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