Gene-targeted non-human mammals deficient in the SOD-1 gene
RW Scott, AG Reaume, EK Hoffman - US Patent 5,814,300, 1998 - Google Patents
… In one aspect, the present invention relates to heterozygous SOD-1 null non-human
mammals, preferably exemplified by a gene-targeted mouse lacking one normal copy (allele) of
SOD-1, thereby producing a reduced amount of Cu/Zn SOD. In a preferred aspect, the invention
relates to homozygous SOD-1 null non-human mammals exemplified by a gene-targeted mouse
lacking both normal copies (alleles) of SOD-1, thereby producing no measurable amount …
Although we disclose herein our most preferred strategy for the development of heterozygous …
mammals, preferably exemplified by a gene-targeted mouse lacking one normal copy (allele) of
SOD-1, thereby producing a reduced amount of Cu/Zn SOD. In a preferred aspect, the invention
relates to homozygous SOD-1 null non-human mammals exemplified by a gene-targeted mouse
lacking both normal copies (alleles) of SOD-1, thereby producing no measurable amount …
Although we disclose herein our most preferred strategy for the development of heterozygous …
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