… the present invention relates to methods of generating endocrine progenitor cells from
human pluripotent stem cells, such as human embryonic stem cells and induced pluripotent
stem cells. Beta-cell transplantation potentially provides the ultimate cure for type I diabetes. …
The present invention relates to methods of generating endocrine progenitor cells from human
pluripotent stem cells, such as human embryonic stem cells and induced pluripotent stem cells. …

The present invention relates to differentiation of stem cells into a homogeneous endocrine
progenitor cell population suitable for further differentiation into pancreatic beta-cells. The
present invention provides methods for obtaining NGN3/NKX2. 2 double positive endocrine
progenitor cells by exposing precursor cells to a TGF-B type I receptor inhibitor, a BMP
antagonist, an adenylate cyclase activator and nicotinamide and/or exposing to the
precursor cells to a selection of small molecules.