Genetic Susceptibility to Hidradenitis Suppurativa and Predisposition to Cardiometabolic Disease

VW Nielsen, OB Vad, N Holgersen… - JAMA …, 2024 - jamanetwork.com
Importance Hidradenitis suppurativa (HS) is associated with an increased prevalence of
cardiovascular diseases compared with the general population. Any association between
polygenic risk for HS, risk of incident cardiometabolic outcomes, and the plasma proteome is
unclear. Objective To investigate the genetic correlation between HS and cardiometabolic
disease. Design, Setting, and Participants This cohort study used a polygenic risk score
(PRS) for HS to examine the risks of coronary artery disease (CAD) and diabetes and …
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