Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and
energy metabolism. Glycolysis in non-oxygen condition is the main energy production
process in cancer rather than mitochondrial respiration as in benign cells. Genetic and
epigenetic alterations of Krebs cycle enzymes favour the shift of cancer cells from oxidative
phosphorylation to anaerobic glycolysis. Mutations in genes encoding aconitase, isocitrate
dehydrogenase, succinate dehydrogenase, fumarate hydratase, and citrate synthase are …