With few exceptions, the marked advances in knowledge about the genetic basis of
schizophrenia have not converged on findings that can be confidently used for precise
experimental modeling. By applying knowledge of the cellular taxonomy of the brain from
single-cell RNA sequencing, we evaluated whether the genomic loci implicated in
schizophrenia map onto specific brain cell types. We found that the common-variant
genomic results consistently mapped to pyramidal cells, medium spiny neurons (MSNs) and …

Background Knowledge of the genetic basis of schizophrenia has markedly improved in the
past five years with the discovery of more than 140 significantly associated loci. Several
gene sets have been implicated in schizophrenia (eg RBFOX, FMRP, synaptic genes).
Precise experimental modelling remains difficult as gene sets consist of hundreds of genes
and the functional effect of perturbations are likely to be cell type dependent. One key that
would allow to model schizophrenia and better understand the disorder is to identify the …