T cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy
driven mainly by oncogenic activation of NOTCH1 signaling. In this study we report the
presence of loss-of-function mutations and deletions of the EZH2 and SUZ12 genes, which
encode crucial components of the Polycomb repressive complex 2 (PRC2),, in 25% of T-
ALLs. To further study the role of PRC2 in T-ALL, we used NOTCH1-dependent mouse
models of the disease, as well as human T-ALL samples, and combined locus-specific and …

T cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy
driven mainly by oncogenic activation of NOTCH1 signaling1. In this study we report the
presence of loss-of-function mutations and deletions of the EZH2 and SUZ12 genes, which
encode crucial components of the Polycomb repressive complex 2 (PRC2) 2, 3, in 25% of T-
ALLs. To further study the role of PRC2 in T-ALL, we used NOTCH1-dependent mouse
models of the disease, as well as human T-ALL samples, and combined locus-specific and …