Observational studies have consistently reported elevated plasma homocysteine as a risk
factor for Alzheimer's disease (AD). However, results from clinical trials of homocysteine-
lowering treatments are inconsistent. This discrepancy may be explained by a lack of causal
association between homocysteine and AD. Mendelian randomization studies have the
potential to provide insight into the causality of this association through studying the effect of
genetic predisposition to high homocysteine on AD. Our analyses using summarized (n …

… Genetic influence of plasma homocysteine on Alzheimer's disease … Homocysteine /
blood* … Homocysteine …