… breast cancer and no BRCA1 or BRCA2 founder mutation carries a damaging mutation in
CHEK2 or another moderate penetrance gene … Most of these mutations are associated with a 2-…

… a complete screening for BRCA1 and BRCA 2 genes in addition to whole gene sequencing
(6… screening BRCA1 and BRCA2 genes is a tedious process due to gene size, high mutation …

… of BRCA1 and BRCA2 founding mutations, estimates of the prevalence of mutations in breast
cancer … Jews, most mutations in these genes are BRCA1 185delAG, BRCA1 5382insC, or …

… where founder mutations have been identified in the BRCA1 and BRCA2 genes (Tables 1 and
2). … BRCA1 and BRCA2 mutations among breast cancer patients from the Philippines. Int J …

… mutational spectra are population - specific and different founder mutations are reported in
different populations 7, 18. Data about ethnicity is also important since it has been shown that …

… developing breast and ovarian cancer, but no other predictor … mutation in the tumour-suppressor
genes BRCA1 or BRCA2. … for gene discovery, founder mutations in BRCA1 and BRCA2 …

… date pertain only to a founder mutation detected in the … breast cancer may have different
effects on three groups: families positive for mutations in BRCA1 or BRCA2, other breast cancer …

… Founder mutations inducing cancer susceptibility have been identified amongst the … as in
Iceland and other regions. The great majority of pathogenic or likely pathogenic mutations (80%…

… mutations in genes other than BRCA1 and BRCA2 to inherited susceptibility to breast cancer
… explained by the three known BRCA1 or BRCA2 founder mutations while a 0.7% combined …

… founder mutation BRCA2 6714delT is approximately half that of women with other BRCA2
mutations… in the terminal exon 27 of BRCA2 that does not appear to increase the risk of breast …