Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study
KL Spencer, J Malinowski, CL Carty, N Franceschini… - PloS one, 2013 - journals.plos.org
Age at menarche (AM) and age at natural menopause (ANM) define the boundaries of the
reproductive lifespan in women. Their timing is associated with various diseases, including
cancer and cardiovascular disease. Genome-wide association studies have identified
several genetic variants associated with either AM or ANM in populations of largely
European or Asian descent women. The extent to which these associations generalize to
diverse populations remains unknown. Therefore, we sought to replicate previously reported …
reproductive lifespan in women. Their timing is associated with various diseases, including
cancer and cardiovascular disease. Genome-wide association studies have identified
several genetic variants associated with either AM or ANM in populations of largely
European or Asian descent women. The extent to which these associations generalize to
diverse populations remains unknown. Therefore, we sought to replicate previously reported …
[PDF][PDF] Genetic Variation and Reproductive Timing: African American
KL Spencer, J Malinowski, CL Carty, N Franceschini… - 2013 - core.ac.uk
Age at menarche (AM) and age at natural menopause (ANM) define the boundaries of the
reproductive lifespan in women. Their timing is associated with various diseases, including
cancer and cardiovascular disease. Genome-wide association studies have identified
several genetic variants associated with either AM or ANM in populations of largely
European or Asian descent women. The extent to which these associations generalize to
diverse populations remains unknown. Therefore, we sought to replicate previously reported …
reproductive lifespan in women. Their timing is associated with various diseases, including
cancer and cardiovascular disease. Genome-wide association studies have identified
several genetic variants associated with either AM or ANM in populations of largely
European or Asian descent women. The extent to which these associations generalize to
diverse populations remains unknown. Therefore, we sought to replicate previously reported …
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