Genetic variation in the genome-wide predicted estrogen response element-related sequences is associated with breast cancer development
Introduction Estrogen forms a complex with the estrogen receptor (ER) that binds to estrogen
response elements (EREs) in the promoter region of estrogen-responsive genes, regulates
their transcription, and consequently mediates physiological or tumorigenic effects. Thus,
sequence variants in EREs have the potential to affect the estrogen-ER-ERE interaction. In
this study, we examined the hypothesis that genetic variations of EREs are associated with
breast cancer development. Methods This case-control study involved 815 patients of Asian …
response elements (EREs) in the promoter region of estrogen-responsive genes, regulates
their transcription, and consequently mediates physiological or tumorigenic effects. Thus,
sequence variants in EREs have the potential to affect the estrogen-ER-ERE interaction. In
this study, we examined the hypothesis that genetic variations of EREs are associated with
breast cancer development. Methods This case-control study involved 815 patients of Asian …
Genetic variation in the genome-wide predicted estrogen response element-related sequences is associated with breast cancer development.
YJC Yu JyhCherng, HCN Hsiung ChiaNi… - 2011 - cabidigitallibrary.org
Introduction: Estrogen forms a complex with the estrogen receptor (ER) that binds to
estrogen response elements (EREs) in the promoter region of estrogen-responsive genes,
regulates their transcription, and consequently mediates physiological or tumorigenic
effects. Thus, sequence variants in EREs have the potential to affect the estrogen-ER-ERE
interaction. In this study, we examined the hypothesis that genetic variations of EREs are
associated with breast cancer development. Methods: This case-control study involved 815 …
estrogen response elements (EREs) in the promoter region of estrogen-responsive genes,
regulates their transcription, and consequently mediates physiological or tumorigenic
effects. Thus, sequence variants in EREs have the potential to affect the estrogen-ER-ERE
interaction. In this study, we examined the hypothesis that genetic variations of EREs are
associated with breast cancer development. Methods: This case-control study involved 815 …
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